LSHTM is seeking to appoint a Trial Manager within the Clinical Research Department. The post-holder will be responsible for the day-to-day operational management of ADVANCING-CM, a multi-site phase IIb into phase III randomised clinical trial of adjunctive interferon gamma for HIV-associated cryptococcal meningitis in Botswana, Malawi, South Africa and Uganda. They will work closely with the International Lead Clinician, the experienced senior trial management team and study coordinators at the participating African study sites. The post-holder will be expected to be based full-time at the Trial Coordinating Centre in Gaborone, Botswana for the duration of study recruitment and to travel frequently to the other trial sites. The role will provide operational leadership across trial set-up, regulatory and ethics processes, site initiation and monitoring, trial documentation, data quality, safety-reporting systems and trial governance, ensuring that the study is conducted in accordance with the protocol, Good Clinical Practice (GCP), applicable regulatory requirements and trial procedures.

The successful candidate will have a postgraduate degree, ideally a doctoral degree, in a relevant topic, relevant experience of working on multicentre phase III clinical trials, including Clinical Trials of Investigational Medicinal Products (CTIMPs), experience of trial set-up and site initiation, including preparation and maintenance of essential trial documentation, experience of clinical trial monitoring, including identification and follow-up of monitoring findings and protocol deviations. Further particulars are available in the job description.

The post is full-time 35 hours per week, 1.0 FTE and fixed term until 31 December 2030. The post is funded by Coefficient Giving and is available from 01 January 2027.

The salary will be on the LSHTM salary scale, Grade 6 in the range £46,643 - £52,909 per annum pro rata (inclusive of London Weighting). The post will be subject to the LSHTM terms and conditions of service.  Annual leave entitlement is 30 working days per year, pro rata for part time staff. In addition to this there are discretionary “Wellbeing Days”. Membership of the Pension Scheme is available. This post is based in Botswana, hosted by the Botswana Harvard Health Partnership Institute in Gaborone with frequent travels to sites in Malawi, Uganda and South Africa. 

Applications should be made on-line via our jobs website. Online applications will be accepted by the automated system until 10pm of the closing date. Any queries regarding the application process may be addressed to jobs@lshtm.ac.uk. Please quote reference ITD-CRD-2026-25.

The supporting statement section should set out how your qualifications, experience and training meet each of the selection criteria. Please provide one or more paragraphs addressing each criterion. The supporting statement is an essential part of the selection process and thus a failure to provide this information will mean that the application will not be considered. An answer to any of the criteria such as "Please see attached CV" will not be considered acceptable. 

Please note that if you are shortlisted and are unable to attend on the interview date it may not be possible to offer you an alternative date.

Closing Date: 19 Nov 2026

Department: Academic

Salary: £46,643 to £52,909 per annum pro rata inclusive

CREATE is an exciting consortium of 5 UK Universities, with 6 partner research institutions in Africa and Asia, funded by Wellcome to train high-calibre health professionals who wish to undertake a PhD as a first step towards a clinical academic career. The 5 UK Universities: London School of Hygiene & Tropical Medicine (LSHTM), Brighton and Sussex Medical School at the University of Sussex (BSMS), University of Sheffield (Ush), University of Bristol (UoB), and University of Southampton (UoSo) have established partnerships with the 6 partner institutions in Asia and Africa: Aga Khan University, Pakistan (AKU), University of Ghana (UoG), University of the Witwatersrand, Johannesburg (Wits), The Biomedical Research and Training Institute, Zimbabwe (BRTI), MRC The Gambia (MRCG), and MRC/UVRI & LSHTM Uganda Research Unit (MRCU). Together these institutions have exceptional resources and an outstanding track record in research and training.

CREATE will support doctoral fellowships for health professionals from all disciplines with an aspiration for developing a research career. This includes doctors, nurses, midwives and all categories of allied health professionals, including pharmacists and healthcare scientists, and those in veterinary medicine, dentistry and all sub-specialties within medicine and surgery. Applicants must have an interest in global health research and successful applicants will develop their potential to become global health leaders within a structured and mentored training environment.

Fellows will register their PhD at one of the 5 UK institutions and will be expected to conduct their research in and spend extended periods of time (18 months minimum) at one of the Programme Africa/Asia partner institutions in Zimbabwe, Ghana, Pakistan, South Africa, The Gambia, and Uganda as part of their PhD. Fellows will all have a primary supervisor in one of the five UK universities and a co-primary supervisor at the Africa/Asia institution where they will based. 

The scope of the research is deliberately broad and must fulfil the following criteria: 1) research will focus on the health problems pertinent to the countries/region where the fellow will conduct their research; 2) research must fulfil the criteria of Discovery Research as defined by Wellcome. Wellcome defines Discovery Research as ‘covering studies across fields and disciplines that lead to new knowledge of life, health and wellbeing’, incorporating disciplinary breath. Projects that range from the fundamentals of biology to the development of new methods, tools and technologies will be within remit. We will also fund population health studies exploring the social, ethical, cultural, political, economic and historical contexts of human health. We encourage inter-disciplinary research ideas and welcome enquiries and applications from those who have had fewer research opportunities so far, but who can evidence great potential for and commitment to a clinical academic career.

On completion of their PhD,  CREATE fellows will receive individually tailored support to develop their research careers.

Applicants must be practicing healthcare professionals and be registered with a national professional regulatory body in the UK/Republic of Ireland (e.g. - General Medical Council, Health and Care Professions Council). Those who have provisional registration or are at pre-registration stage are not eligible to apply. All applicants must have a minimum of two years of clinical experience following their qualification to be eligible to apply. Medical graduates must be registered on a UK/Republic of Ireland training programme or be a registered GP. Those who are on a training programme will have a minimum 12 months left to complete their CCT in their chosen specialty by the time the PhD is awarded. Nurses, midwives and allied health professionals (NMAHPs) must have a Masters Degree in a relevant field. Applicants must have the right to work in the UK and be eligible for UK/home fees.

Applicants should maintain their clinical skills, if applicable. Support is for three years and includes a salary, research expenses, home rate tuition fees, and training and travel costs. 

Wellcome’s definition of a health professional can be found here. Appointments will be made to match an appointee’s current salary plus London allowance if applicable.  Every effort will be made to match NMAHP salaries to the Agenda For Change scale.

The application is a two-stage process. The Stage 1 process is an online application form that will consider the applicant’s suitability for the CREATE PhD Programme including their motivation to undertake doctoral research training, and their vision of their PhD research and their career. Each question in the application form should be completed, adhering to the word limit. Failure to comply will result in the application not being considered. 

Approximately 15-20 applicants will be selected from Stage 1, and be invited to develop a full Stage 2 application comprising a competitive PhD proposal with a detailed budget and to find relevant supervisors to adhere to the required supervision model described above. Up to five applicants will be selected for funding following external peer review and interview in May 2027.  If successful, fellows will be required to take up the fellowship within 12 months of the award being made. 

Applications for Stage 1 should be made via: http://jobs.lshtm.ac.uk. Online applications will be accepted by the automated system until 23.59 of the closing date. Applicants should not upload a CV. An Equal Opportunities form should be submitted alongside the application to Nunzia.limongelli@lshtm.ac.uk Please quote reference ITD-CRD-2026-24.

Closing date for the receipt of applications is Sunday 8^th November 2026.

If you have any questions about the application process, please email us at create-phd@lshtm.ac.uk

Further information on the Programme is available at: PROGRAMME | CREATE PhD Programme (create-phd.org) 

Closing Date: 08 Nov 2026

Department: Academic

Salary: £45,728 to £76,582 per annum pro rata inclusive